DETERMINATION OF THE DNA DAMAGE LEVELS IN PATIENTS WITH CHRONIC RENAL FAILURE USING 8-HYDROXY-2 '-DEOXYGUANOSINE BIOMARKER

Abstract

An important DNA oxidation product is 8-hydroxy-2'-deoxyguanosine (8-OHdG). DNA bases guanine and deoxyguanosine are DNA bases that are more susceptible to oxidation due to their low ionization potential and 8-OHdG is a useful biomarker used as an indicat