• Login
    View Item 
    •   DSpace Home
    • 2-DERGİLER
    • 03) Bitlis Eren Üniversitesi Fen Bilimleri Dergisi
    • Cilt 11, Sayı 2 (2022)
    • View Item
    •   DSpace Home
    • 2-DERGİLER
    • 03) Bitlis Eren Üniversitesi Fen Bilimleri Dergisi
    • Cilt 11, Sayı 2 (2022)
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Genipin Crosslinked Human Serum Albumin Nanoparticles

    Thumbnail
    View/Open
    Tam Metin/Full Text (1.768Mb)
    Date
    2022
    Author
    KURTUL, Emine Dila
    ÇAPKIN YURTSEVER, Merve
    Metadata
    Show full item record
    Abstract
    The use of human serum albumin (HSA) nanoparticles as drug delivery systems in controlled drug release studies has gained importance today. Albumin nanoparticles are biocompatible, biodegradable and provide sustained release. To maintain longterm drug delivery, HSA nanoparticles need to be cross-linked. A chemical crosslinker, glutaraldehyde is generally used in the literature and has some toxic effects on the cells. In this study, a biological crosslinker, genipin, was used for the production of HSA nanoparticles by desolvation technique. Two different temperatures and genipin concentrations were studied in order to decrease crosslinking time. The nanoparticles were characterized by Scanning Electron Microscopy (SEM) and Dynamic Light Scattering (DLS). The crosslinking time was reduced from 8-24 hours to 2 hours by raising the temperature to 37oC from room temperature. HSA nanoparticles which are crosslinked by genipin may have potential use in drug delivery system and may be applied in personalized medicine applications.
    URI
    http://dspace.beu.edu.tr:8080/xmlui/handle/123456789/14646
    Collections
    • Cilt 11, Sayı 2 (2022) [35]





    Creative Commons License
    DSpace@BEU by Bitlis Eren University Institutional Repository is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 Unported License..

    DSpace software copyright © 2002-2016  DuraSpace
    Contact Us | Send Feedback
    Theme by 
    Atmire NV
     

     




    | Yönerge | Rehber | İletişim |

    sherpa/romeo

    Browse

    All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsBy TypeThis CollectionBy Issue DateAuthorsTitlesSubjectsBy Type

    My Account

    LoginRegister

    DSpace software copyright © 2002-2016  DuraSpace
    Contact Us | Send Feedback
    Theme by 
    Atmire NV