The antioxidant effect of boric acid and CoQ10 on pulmonary fibrosis in bleomycin induced rats
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Date
2012Author
Çelikezen, Fatih Çağlar
Oto, Gökhan
Özdemir, Hülya
Kömüroğlu, Ufuk
Yörük, İbrahim
Demir, Halit
Çilingir Yeltekin, Aslı
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The purpose of this study is to investigate the antioxidant effects boric acid and CoQ10 has on
pulmonary fibrosis in bleomycin induced rats. 32 wistar albino male rats were used in this study. The
rats were categorised in four groups; a control group (only given normal saline), a bleomycin (BLM)
group, a BLM + boric acid group, and a BLM + boric acid + CoQ10. The study period was adjusted to 30
days. Retinol, vitamin E, vitamin D, catalase, carbonic anhydrase, glucose, total protein, albumin,
globulin, and total bilirubin levels were measured at the end of the study. There was a significant
increase in the vitamin E levels of all groups (p<0.05). There was a statistically significant increase in the
glucose level of all groups (P<0.001). There were significant decreases in albumin and total protein
levels of all groups. While the significance level of the decrease in the albumin level was p<0.001, the
significance level of the decrease in the total protein level was p<0.05. There was no significant
difference in other biochemical parameters.
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