Combined Treatment with Tauroursodeoxycholic Acid and SCD Probiotics Reduces Oxidative Stress in Lung Tissue of Aged Rats

Abstract

Aging is associated with an increased level of oxidative stress, resulting from an elevated production of reactive oxygen species, which can lead to cellular and tissue damage, particularly in the lungs. In this study, it was aimed to evaluate the effects of tauroursodeoxycholic acid (TUDCA) and SCD Probiotics, both individually and in combination, on malondialdehyde (MDA), advanced oxidation protein products (AOPP), and myeloperoxidase (MPO) levels as oxidative stress markers in the lung tissue of aged Sprague-Dawley rats. The results showed that TUDCA significantly decreased MDA and AOPP levels, suggesting its antioxidant activity. SCD Probiotics also demonstrated a reduction in AOPP levels, highlighting their immunomodulatory and antioxidant effects. Furthermore, the combined treatment of TUDCA and SCD Probiotics resulted in a significant reduction in both MDA and AOPP levels, as well as a notable decrease in MPO activity. This suggests a synergistic interaction that enhances the antioxidative and anti-inflammatory properties of the individual treatments. These findings support the therapeutic potential of TUDCA and SCD Probiotics in mitigating oxidative damage in aging lung tissues, suggesting that their combined use may be a promising approach to combat age-related oxidative stress. Further research is needed to investigate these effects in various models and long-term applications.