An Investigation into the Electrochemical Behavior of Beta-Blocker Drugs Using Reduced Graphene Oxide Modified Screen Printed Electrodes

Abstract

In this study, the electrochemical behavior of propranolol was investigated on screen printed electrodes (SPCE) with reduced graphene oxide (rGO). Oxidation process, cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques were conducted by using measurements. The results showed that rGO increased the oxidation rate by increasing the peak current, and therefore oxidizing these drugs at appropriate potentials. The modified SPCE exhibited excellent catalytic activity towards oxidation of the beta-blockers at an unusually positive potential in phosphate buffer solution (PBS). The linear concentration range and the detection limit of the proposed sensor for the detection of propranolol was 5- 50 µM and 2.61 µM, respectively