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    • 02) Bitlis Eren University Journal of Science and Technology
    • Cilt 02, Sayı 1 (2012)
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    • 2-DERGİLER
    • 02) Bitlis Eren University Journal of Science and Technology
    • Cilt 02, Sayı 1 (2012)
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    The antioxidant effect of boric acid and CoQ10 on pulmonary fibrosis in bleomycin induced rats

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    Date
    2012
    Author
    Çelikezen, Fatih Çağlar
    Oto, Gökhan
    Özdemir, Hülya
    Kömüroğlu, Ufuk
    Yörük, İbrahim
    Demir, Halit
    Çilingir Yeltekin, Aslı
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    Abstract
    The purpose of this study is to investigate the antioxidant effects boric acid and CoQ10 has on pulmonary fibrosis in bleomycin induced rats. 32 wistar albino male rats were used in this study. The rats were categorised in four groups; a control group (only given normal saline), a bleomycin (BLM) group, a BLM + boric acid group, and a BLM + boric acid + CoQ10. The study period was adjusted to 30 days. Retinol, vitamin E, vitamin D, catalase, carbonic anhydrase, glucose, total protein, albumin, globulin, and total bilirubin levels were measured at the end of the study. There was a significant increase in the vitamin E levels of all groups (p<0.05). There was a statistically significant increase in the glucose level of all groups (P<0.001). There were significant decreases in albumin and total protein levels of all groups. While the significance level of the decrease in the albumin level was p<0.001, the significance level of the decrease in the total protein level was p<0.05. There was no significant difference in other biochemical parameters.
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    http://dspace.beu.edu.tr:8080/xmlui/handle/123456789/13754
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    • Cilt 02, Sayı 1 (2012) [8]





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